Home > Dermatology > Early Signs of Skin Cancer Get the Flash Player to see this player. Rate: (Click the stars to rate) Published on Oct 10, 2009 by MConroy, Views: 3983 Early signs of skin cancer. You need to check your whole body for suspicious lesions. You need to remember the ABCDE of skin: A-Asymetry of skin lesion- or irregular, B-border of the lesion- also irregular is suspicious, C-color- multiple colors are worrisome, D-diameter- those larger than a pencil eraser are worrisom, and E-evolution- moles or lesions that change over time. Dr. Maria Riza Conroy. Ohio State University.