Home > Mental Health > How Antidepressannts FIght Depression Get the Flash Player to see this player. Rate: (Click the stars to rate) Published on Sep 26, 2008 by KRobbins, Views: 4018 Depression is the most common mental illness. It is important to recognize the symptoms of depression. Clinical depression usually does requires treatment with medications. The treatment of depression differs in patients with manic depression. A psychiatric evaluation will guide the treatment of depression.