Home > Men's Health > PSA, What Does Having a High PSA Mean? Get the Flash Player to see this player. Rate: (Click the stars to rate) Published on Feb 08, 2009 by GaryOnik, Views: 8410 What does having a high PSA mean? Dr. Gary Onik, a noted radiologist who specializes in prostate cancer, discusses what is means for a man who has an elevated PSA. There are a number of conditions that can contribute to having an elevated PSA. There are also other blood tests that can be checked that help determine the reason you may have an elevated PSA.