Home > Cholesterol > Prognosis With High Cholesterol Get the Flash Player to see this player. Rate: (Click the stars to rate) Published on Oct 05, 2008 by SRBergmann, Views: 6619 High Cholesterol is one of the major risk factors for atherosclerosis, which is the cause of heart attack and stroke. With adequate treatment of high cholesterol, including a low fat, low cholesterol diet, exercise, and sometimes medications to help lower blood cholesterol, the prognosis is very good. Along with the treatment of the other risk factors for atherosclerosis, lowering blood cholesterol can lower your chance of having a heart attack or stroke.