Home > Heart Disease > Heart Transplant Get the Flash Player to see this player. Rate: (Click the stars to rate) Published on Jun 26, 2008 by JohnDark, Views: 5184 Dr John Dark discusses heart transplant for the treatment of cardiomyopathy. Cardiomyopathy is a weakening of the heart muscle. The most common cause is from ischemia from blockage in the heart arteries, but other causes include viral cardiomyopathy. In people with refractory heart failure-CHF, or fluid build up, on good medicines, some will need a heart transplant.