Home > JAMA REPORT > Gene Linked to Vision Loss in Old Age Get the Flash Player to see this player. Rate: (Click the stars to rate) Published on Feb 26, 2008 by JSeddon, Views: 7602 JAMA Reports: Macular Degeneration is the leading cause of blindness in people over age 55, and leads to vision loss in 25% of people over age 75. A new study in JAMA shows that having a certain gene plays a role in addition to other risk factors, including smoking, and being overweight. Dr. Johanna Seddon. Tufts-NEMC. Boston, MA.