Home > Vascular Disease > Lymphedema Get the Flash Player to see this player. Rate: (Click the stars to rate) Published on Dec 12, 2009 by GPhotopulos, Views: 3335 Lymphedema: Dr. Guy Photopulos, a surgical oncologist, reviews lymphedema, which is essentially severe leg swelling. Some patients have primary lymphedema, meaning it is not from another cause. But most cases are secondary to another problem, such as trauma, surgery, cancer. In addition to pain in the legs, and difficulty with ambulation, skin problems, such as skin infections are the major complications from lymphedema.