Home > Vascular Disease > Marfans Syndrome Get the Flash Player to see this player. Rate: (Click the stars to rate) Published on Nov 26, 2009 by CBruce, Views: 3683 Marfans syndrome is a connective tissue disorder. Outwardly the people that have marfans syndrome are usually very tall and lanky, with a long arm span. The main problem that people with marfans syndrome develop is that their Aorta, the main blood vessel of the body, becomes enlarged. The treatment to prevent an Aortic dissection, or a tear in that large artery is frequently surgical. Dr. Charles Bruce, Mayo Clinic.