What is multiple myeloma? Dr. Morie Gertz from the Mayo Clinic discusses Multiple Myeloma at the IMF. Mutiple Myeloma is a malignancy of the bone marrow, when cells in the marrow grow without restraint and replace the normal bone marrow. It causes anemia, which causes symtpoms of fatigue, and loss of energy. Another symptom can be bone pain. Some patients will need stem cell transplantation for treatment.